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« Men don’t get colon cancer, right?
How is a polyp removed? »

What is a polyp anyway?

In response to yesterday’s posting of an advanced circumferential colon cancer, a reader asked me to post a picture of what the normal colon looks like:

Example of normal colon (as seen during colonoscopy)
Example of normal colon (as seen during colonoscopy)

The thing is that you don’t go to bed one night with an entirely normal colon and wake up the next day with colon cancer!

The current thinking and current evidence suggests that pretty much all colon cancer comes from “pre-cancerous polyps” that have grown over time and transformed into colon cancer.

 

 

 

 

 

 

 

 

 

 

 

How a polyp becomes a cancer...

How a polyp becomes a cancer...

 A polyp is any “mucosal protuberance.” 

 

Mucosa is that slippery tissue that makes up certain parts of our bodies.  One readily apparent example of mucosa is the inside lining of your mouth/cheek.  That slippery, wet, pinkish tissue inside your mouth that gets burned when you eat cheese pizza that is too hot is known as “buccal mucosa.”

This is similar tissue to what makes up the inside lining of your colon - the colonic mucosa.
When growths develop on the inside of the colon wall, they are called colon polyps.
Colon polyps come in different sizes, shapes and “personalities”.
Polyps can be small, medium or large in size:
A small polyp
A small polyp
A medium-sized polyp
A medium-sized polyp
large-polyp
A large polyp

I often describe polyps to my patients as “mushrooms growing on the colon wall.”  Sometimes they are like the mushroom cap, in which case we call them “sessile.”  The first two (small and medium) are examples of sessile polyps.

Other times, they have a stem to them (like the large polyp above and one below), in which case we call it “pedunculated”:

Notice the lollipop stem!
Notice the lollipop stem!

 

The “personality” of the polyp refers to its “histopathologic tissue type” when analyzed under a microscope by a pathologist (a doctor who specializes in looking at tissue under a microscope).
Polyps that daydream about  becoming colon cancer are called “adenomas” (noun) or “adenomatous” (adjective). 
Within this family of polyps there are degrees to which they aspire to become cancer.
 
One type is called “tubular adenoma” - it is your run-of-the-mill “pre-cancerous polyp.”
 
Another type is called “villous adenoma”.  This is the “villainous” one that REALLY wants to be a cancer. 
 
 In between these two, you have a pre-cancerous type that just can’t decide how bad it really wants to be - so it is called “tubulovillous” to show its mixed-up nature.
 
In contrast to this, there are “hyperplastic” polyps.  Hyperplastic polyps are an overgrowth of normal tissue.  Without getting too in to it, let’s say that they are, by themselves, not considered pre-cancerous.  You can think of them kinda like skin-tags.  When analyzed at a certain angle by the pathologist, they can have a jagged sawtooth appearance, so they can also be called “serrated,” like a knife.
 
To keep it interesting, there is yet another “personality” type  known as “serrated adenoma.”  As the name suggests, this particular one doesn’t know if it wants to be a goodie (”serrated”) or a badie (”adenoma”).  It is therefore considered guilty until proven otherwise - - and is treated like a pre-cancerous adenoma.
 
 
Well, that’s enough for now.
 
More on polyps tommorow…

This entry was posted on Wednesday, March 4th, 2009 at 12:01 am and is filed under Colon Cancer Awareness. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

One Response to “What is a polyp anyway?”

  1. Wendy Says:
    March 4th, 2009 at 8:42 pm

    How long does it take for a polyp to make the change into cancer?

Leave a Reply

    Colon Cancer Awareness
    By Dr. Todd N. Witte
    Dr. Todd N. Witte of Northwest Gastroenterology in Bellingham will discuss colon cancer issues and answer your questions thoughout March, which is designated as Colon Cancer Awareness Month.

    Colon cancer is the second-leading cause of cancer-related deaths, and the third-most common cancer behind lung, breast and prostate cancer. Colon cancer is preventable if pre-cancerous growths, which are called "polyps," can be detected and removed. If colon cancer is detected early, it is beatable in more than 90 percent of cases. Less than two-thirds of those who should be screened for colon polyps or early colon cancer are checked.

    Witte is board-certified in both internal medicine and gastroenterology. He is one of eight board-certified gastroenterologists at Northwest Gastroenterology, the largest single-specialty doctors office focusing on the "gut" healthcare of Whatcom County residents. Witte earned his medical degree at the Medical College of Virginia/Virginia Commonwealth University. His internal medicine residency and specialty gastroenterology fellowship were completed at The George Washington University Hospital in Washington D.C. He has practiced medicine in Australia and has participated in advanced endoscopic training through the University of British Columbia. Witte performed more than 1,000 endoscopic procedures last year.
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